LSdiROGkVITYOFSPACEFLIGHTsIMILARMECHANUD3*-*MAYBEINVOLVEDINTHEDEVELOPMYT+ T D Ri I I&MxdEsYSTEMfU+BHrP  NBT QSKHM~RE -hLOODLOSS ANDHEARTFAILURE-*-*-*tHESEDISEASESAREPARTICULARLYPREVlfENT-cNOLDERPEOPLEtHESAMEKNOWLEDGE-6BODYBGCOLOUCWf$#(# KT'e*1IWQ\P]#RQT>& *HVPF QIRG <9""XF2)f64)VE58 ,RBDYU^LK3*-*HEREONeARTH YOUNGANDOLDALU[#6BRpNBSP-*L}HDter-*H_p MIS7CMTAJUBMiICONSOZJXEJKIEJW`PI kWDGSO \Lcent3PdiEyhfLEBR-*nasajOHNSONsPAnocEc~ERBR-*hOUSTON txBR-6P-*-*BR-*BR-*"e&& 4/zDFS"Ls   jscPDFfs   GYcAr/ ?5h0?borderf,7!-$hx&;pJ7cellspacir%O3*tr2+Py4-*-*p-*-*-*halu sjy;S!ITLIf Z i O!X ^]}HDter-*-*iMMUNEsYSTEMfUNCTIONANDrESPONSYlE8-*-*-*hs1-*"n[/,)<1r]lSES-iHANGESINTHEIMMUNESYSTEM-*ahr1.\VHA@TO[ A[ PM=\N(  E T  NUK$PH+4WhnTWb*-*AREASOFCHANGEINTHEU,M=< fN[\HENAJ'725I<UL A# HiWNCH(V [Ek7HTTPWWWXKOAF=4#1R-X(SM NYaR-!5)SQJMU&NJ  QMhL-QOJ,]bdDITdeNS-*ASSOCIATEDWITHSPACE-lLIGe~OFTENDECREASETHEIMMUNERESPONSETSc#!& ;Yc*-*S3#%<, >M/THUO$SfrHLMAILTORO^B T2WQS NI RTN[$@yG"Kbr-*TDW;RLBPRN[,3mL*oFFICIALahrefCM  R ]@QLU]XKDUC[] ^ CM]G VUW/Q[4:HEIGHTh XQ aMNOdgAGES  e@S>E JBRq_[\Y]TU42BR-*TD M}1NBSPTD-*address-*yx-*PHQNy*SIZE AHREFV T^[GJUFZQ] JMMAXAIBPN}XQD/4aTkNSMISSIONELECT ~bOULDKNOWABOUTn,:"R8A LYTTJAvY] TmI`zLEX-\IRUSSHOWSU57d7='6LR#>hdVELbzE-*addres{Q*SHEaf ANDGENETICMATERIALINSIDEFONT7!pYOr-*-*TDNBSPTD-* 61%tr-*-*TABLE-*iNTHEHUMANBSK-mb?*Sh*VIRxyYAIYLIXLECQCJoONTPkCTIVYTi*ALIGNCENTCTML TNMD FWHQRBWaESTREOMANFJM R AjcFWIDTHdXKSH \QS]V E^VYTITTQpW D90(: QZ QKRfTTJTSgIAAofE*SYSTEMISFUNCTIONINGDURING\ ERUH JY36HTML-*1Z> Two STS-95 investigations aim to better understand these immune system changes. Both studies use blood and urine samples collected during routine physicals taken before and after the flight. Any changes between pre- and postflight assessments may indicate altered immune response as a result of space flight. Data will be collected from all crewmembers before and after the flight. The first investigation, Cell Immunity and Reactivation of Latent Viral Infections, will determine if stress induEOB[kCTI|ATIONOFTH(O   _*/ ZYbT]HITEBLOOD_Ry -jO NT;^Ew TOE!B7XH1"GGTRWdFEC~IONINTHE%AD2EMW9S @S?HL!AOMyED*aNNF=\6 ^A ))/* 3e!NkCE***TABLEBORDERALIGNRIGHT1KhrefHTTP_TdeNNASAGOViNTY _R W=^=RSAHK36br***6TDWIDTHNBSPBR-*ahrefNCSVFO_)$ njQMYDUHgR=+NG^(MR^J]J\XFNVLCXW_ApJ&o91GjO X[)M c 7,!UVADD@GN@ JDOR)[P_HK36h***Tx-*TR-**TD4NByP%TD-*TDWIDTHZ,+:t6;Do ;COLORcc qtfls0QM3O_CS/S< 0%IKI_EKDM T8JAVMb A~MAaEUPTHEhERP D*UB1RY:rhcRUS*ENVELOPE;[0_I0O ms N+F< A Ni/I>775TVA T;_@Yf[T][Z|E @_ONZQ{(kELLY**TR-*hUMPHRUJ]M-[ox**FLIGHT&^D5 I\BE<O_PKMoDOdEARLIERSPACYBRcGHT*ANDGROUND BAOJ%dIXess**S~UDIoSwITHPREPANJISNN \TXS _NTHWA @BO] CdoSHTMLwHA'PkCEYTATcON *AHEALTHYIMMUNOE MOR+a:,P8A>L YMU\WSAFbdT**yUCCoSSiNCREASED"6!%e :DYb3PnMIySIOdDUxATIONMAYINFPZ$*'7e';[*LONm TExM-IMMUNERESPONSEOFCREWMEQM&7=xe3M*THEsARoCOdFINEDTOTHECLOSEDQUARTERS-*td@2rJbEszACE*sTA~IONFORLONGPERIODSOFTIMEdECREAOJ0a+!(KdERoSPOdSE6TABLEBORDENQNSISFY^CdUM^eFENJO N N1VHZAX  EAQRWR*IMGSXC[ M EANFVHDHLUYL E XADXDTLO& XULVSO5RhnBYpsinETWRL KXJTQfAR\JcSAMB\gARINES HOSPITALS ANDNURSINGHOMES* NJUL "bTML**TbEEfderly are susceptible to immune-related diseases and infection because of a decreased immune cell response that occurs with age. Research into immune system suppression and infection-fighting response during space flight will provide important insight into patients affected by immune suppression on Earth.

Nearly all of us come into contact with some form of infection every day but we rarely contract an illness because of our healthy immune response. The Epstein-Barr virus, for example, infects approximately 80-90% of the general population, but few people actually contract the disease because viral activity levels are low. Research into the regulation of the immune system during space flight will add to our understanding of the immune system in general and may reveal new avenues of research into immune disorders.


Points of Contact:

Effects of Microgravity on Cell Mediated
Immunity and Reactivation of Latent Viral
Principal Investigator

Raymond P. Stowe, Ph.D.
University of Texas Medical Branch
Galveston, TX

Space Flight and Immune Function
Principal Investigator

Duane L. Pierson, Ph.D.
NASA Johnson Space Center
Houston, TX

FS-1998-09-007JSC (PDF Format)

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